What is a Gastrointestinal Stromal Tumor (GIST)

GIST – Gastrointestinal Stromal Tumor

  • GISTs may be malignant or benign
  • More common in the stomach and small intestine but can be found anywhere along the GI tract.
  • Begins in cells called th interstitial cells of Cajal (ICC) – considered the pacemakers of the GI tract
  • GIST may have a genetic component. ¬†Neurofibromatosis type 1 is linked to GIST.
  • Partial resections are usually adequate with GIST treatment with negative margins. ¬†Formal gastrectomy is not usually necessary, nor is partial gastrectomy with nodal dissection. ¬†Organ sparing approaches are usually appropriate.

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