Category Archives: Medullary Thyroid Cancer

What is the RET proto-oncogene?

RET Proto-Oncogene

From an insurance standpoint on RET proto-oncogene testing for MTC – found on the internet:

Aetna considers diagnostic testing for germline point mutations in the RET gene medically necessary for members with apparently sporadic medullary thyroid carcinoma.

What is a proto-oncogene?

A proto-oncogene is a normal gene which can become an oncogene due to mutations or increased expression.

Ectopic ACTH production

Ectopic ACTH Syndrome

Also known as EAS

Sources of Ectopic ACTH production.

  • Lung = most common cause.
  • Thymus
  • Thyroid – Medullary carcinoma
  • Ovary
  • Adrenal Gland – pheochromocytoma
  • Liver
  • Pancreas
  • Other neuroendocrine cancers

Difference between Cushings syndrome and Cushings disease

  • Cushings syndrome is cortisol excess from any cause.
  • Cushings disease is cortisol excess by pituitary ACTH over-secretion

Presentation found on the internet regarding Ectopic ACTH production: